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Used with adjectives:
"
The story has enormous significance."
(enormous, great, historic, immense, major, profound, real, considerable)
"
What is the wider significance of the discovery?"
(wider, broader, full, general, universal)
"
This desk has special significance to my family."
(special, particular)
"
That book has major cultural significance."
(cultural, historical, religious, spiritual, social, moral, political, economic)
Used with verbs:
"
The ring has great significance to her mom."
(has, holds)
"
We want to understand the true significance of his stories."
(understand, appreciate, grasp, recognize, see)
"
Please don't attach too much significance to what he says."
(attach, assume)
"
We need to determine their significance to this situation."
(determine, assess)
Used with prepositions:
"
This house has a special significance for my family."
(for)
"
I didn't understand the significance of the event."
(of)