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Used with verbs:
"
His injury looks serious."
(looks, seems, sounds, be: is/am/are)
"
Her infection got more serious."
(got, became, grew)
"
Can you be serious for once?"
(be, looks, sound, act, remain, stay)
Used with adverbs:
"
The results were extremely serious."
(extremely, really, terribly, particularly, very, fairly, somewhat, quite)
"
The infection is potentially serious."
(potentially)
Used with prepositions:
"
The situation has become very serious for everyone."
(for)
"
Are you serious about quitting your job?"
(about)
Used with nouns:
"
He had a serious injury."
(injury, heart attack, concussion, sprain, injury, infection, wound, voice, disease, disorder)
"
This is a serious crime."
(crime, problem, accident, matter, incident, situation, question, issue)
"
She made a serious mistake."
(mistake, error, blunder, threat, miscalculation, effort)
"
He is in serious trouble."
(trouble, need)